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https://apo.ansto.gov.au/dspace/handle/10238/3029| Title: | An investigation into the potential of SarAr for use in Cu-64 radioimmunotherapy. |
| Authors: | Di Bartolo, N Smith, SV Hetherington, ELR Sargeson, A |
| Keywords: | Radioimmunotherapy Iodine 123 Copper 64 Mice Dosimetry Drugs |
| Issue Date: | 13-Oct-2009 |
| Publisher: | CSIRO Publishing |
| Citation: | Di Bartolo, N., Smith, S. V., Hetherington, E., & Sargeson, A. (2009). An investigation into the potential of SarAr for use in Cu-64 radioimmunotherapy. Australian Journal of Chemistry, 62(10), 1261-1270. doi:10.1071/CH09369 |
| Abstract: | The B72.3 monoclonal antibody was radiolabelled with 123I, and with 111In and 64Cu, using DTPA and SarAr, respectively. Their biodistribution in tumour-bearing nude mice was used to calculate the dosimetry of their respective therapeutic analogue, using 131I, 90Y, 67Cu, and 64Cu. Two dosimetry models were used: one using the classical approach and a second model that takes into consideration the chemical stability of the radiolabelling methods employed and the biological clearance of each radioimmunoconjugate. Results clearly show that the 64Cu-SarAr-B72.3 could be used as a therapeutic agent and, theoretically, be at least as effective as any of the other therapeutic radionuclides currently studied, such as 131I, 90Y, and 67Cu. © 2009, CSIRO Publishing |
| Gov't Doc #: | 1585 |
| URI: | http://dx.doi.org/10.1071/CH09369 http://apo.ansto.gov.au/dspace/handle/10238/3029 |
| ISSN: | 0004-9425 |
| Appears in Collections: | Journal Articles |
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