Imaging cancer using PET - the effect of the bifunctional chelator on the biodistribution of a 64Cu-labeled antibody.

Please use this identifier to cite or link to this item: https://apo.ansto.gov.au/dspace/handle/10238/3099

Title:	Imaging cancer using PET - the effect of the bifunctional chelator on the biodistribution of a 64Cu-labeled antibody.
Authors:	Dearling, JLJ Voss, SD Dunning, P Snay, E Fahey, F Smith, SV Huston, JS Meares, CF Treves, ST Packard, AB
Keywords:	Mice Copper 64 Labelling Thermodynamics Radioisotopes Neoplasms
Issue Date:	1-Jan-2011
Publisher:	Elsevier
Citation:	Dearling, J. L. J., Voss, S. D., Dunning, P., Snay, E., Fahey, F., Smith, S. V., Huston, J. S., Meares, C. F., Treves, S. T., Packard, A. B. (2011). Imaging cancer using PET - the effect of the bifunctional chelator on the biodistribution of a 64Cu-labeled antibody. Nuclear Medicine and Biology, 38(1), 29-38. doi:10.1016/j.nucmedbio.2010.07.003
Abstract:	Use of copper radioisotopes in antibody radiolabeling is challenged by reported loss of the radionuclide from the bifunctional chelator used to label the protein. The objective of this study was to investigate the relationship between the thermodynamic stability of the 64Cu-complexes of five commonly used bifunctional chelators (BFCs) and the biodistribution of an antibody labeled with 64Cu using these chelators in tumor-bearing mice. © 2011, Elsevier
Gov't Doc #:	3236
URI:	http://dx.doi.org/10.1016/j.nucmedbio.2010.07.003 http://apo.ansto.gov.au/dspace/handle/10238/3099
ISSN:	0969-8051
Appears in Collections:	Journal Articles

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