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https://apo.ansto.gov.au/dspace/handle/10238/5397| Title: | Protein surface and core dynamics show concerted hydration-dependent activation |
| Authors: | Wood, K Gallat, FX Otten, R van Heel, AJ Lethier, M van Eijck, L Moulin, M Haertlein, M Weik, M Mulder, FAA |
| Keywords: | Hydration Isotopes Neutron spectroscopy Proteins Enzyme activity Myoglobin Lysozyme Glass |
| Issue Date: | 1-Jan-2013 |
| Publisher: | Wiley-V C H Verlag GMBH |
| Citation: | Wood, K., Gallat, F. X., Otten, R., van Heel, A. J., Lethier, M., van Eijck, L., Moulin, M., Haertlein, M., Weik, M., & Mulder, F. A. A. (2013). Protein surface and core dynamics show concerted hydration-dependent activation. Angewandte Chemie International Edition, 52(2), 665-668. doi:10.1002/anie.201205898 |
| Abstract: | By specifically labeling leucine/valine methyl groups and lysine side chains “inside” and “outside” dynamics of proteins on the nanosecond timescale are compared using neutron scattering (see picture). Surprisingly, both groups display similar dynamics as a function of temperature, and the buried hydrophobic core is sensitive to hydration and undergoes a dynamical transition. © 2013, Wiley-VCH Verlag GmbH & Co. KGaA |
| Gov't Doc #: | 4752 |
| URI: | http://dx.doi.org/10.1002/anie.201205898 http://apo.ansto.gov.au/dspace/handle/10238/5397 |
| ISSN: | 1433-7851 |
| Appears in Collections: | Journal Articles |
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