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https://apo.ansto.gov.au/dspace/handle/10238/5564| Title: | Olanzapine differentially affects 5-HT2A (and 2C) receptor mRNA expression in the rat brain |
| Authors: | Huang, XF Han, M Huang, X Zavitsanou, K Deng, C |
| Keywords: | Weight Metabolic diseases Dopamine Serotonin Genes Diet |
| Issue Date: | 10-Aug-2006 |
| Publisher: | Elsevier Science BV |
| Citation: | Huang, X. F., Han, M., Huang, X., Zavitsanou, K., & Deng, C. (2006). Olanzapine differentially affects 5-HT2A (and 2C) receptor mRNA expression in the rat brain. Behavioural Brain Research, 171(2), 355-362. doi:10.1016/j.bbr.2006.03.040 |
| Abstract: | This study examined regional changes in rat brain mRNA levels encoding 5-HT2A and 5-HT2C receptors following chronic olanzapine treatment. The immediate effect (2 h after the last treatment) was a down-regulation of 5-HT2A receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48 h later. 5-HT2C receptor mRNA expressions were decreased in the substantia nigra. Correlations between 5-HT2A receptor mRNA expression and total food intake, weight gain and energy efficiency were observed. © 2006, Elsevier Ltd. |
| Gov't Doc #: | 4524 |
| URI: | http://dx.doi.org/10.1016/j.bbr.2006.03.040 http://apo.ansto.gov.au/dspace/handle/10238/5564 |
| ISSN: | 0166-4328 |
| Appears in Collections: | Journal Articles |
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