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Title: Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts
Authors: Pascali, G
Del Carlo, S
Rocchiccioli, S
Signore, G
Saccomanni, G
Manera, C
Macchia, M
Salvadori, PA
Keywords: Salts
Positron computed tomography
Nuclear magnetic resonance
High-performance liquid chromatography
Issue Date: 24-Aug-2014
Publisher: Springer Nature
Citation: Pascali, G., Del Carlo, S., Rocchiccioli, S., Signore, G., Saccomanni, G., Manera, C., Macchia, M., & Salvadori, P. A. (2015). Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts. Journal of Radioanalytical and Nuclear Chemistry, 303(1), 1021-1027. doi:10.1007/s10967-014-3407-4
Abstract: The use of direct radiofluorination of aryliodonium salts represents a promising route to new PET tracers. This study tested the use of these precursors for obtaining candidate ligands of the cannabinoid type-2 receptor. 18F-labelling was performed using microfluidic technology, which allowed obtaining good incorporation yields. A closer inspection of the chemical composition of the reaction mixture evidenced the recurrent occurrence of chemical byproducts (H-adduct) due to a reductive side reaction of these substrates. The H-adduct formation seems to be unrelated to water presence, needed for obtaining a satisfactory incorporation, and may become an important feature for assessing the real-life accessibility of new radiotracers through the use of aryliodonium precursors. © 2014 Akadémiai Kiadó, Budapest, Hungary
Gov't Doc #: 8842
ISSN: 1588-2780
Appears in Collections:Journal Articles

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